A New Diterpenoid with Antispasmodic
Activity from Salvia cinnabarina
Giovanni Romussi1,*,
Giovanni Ciarallo1, Angela Bisio2, Nadia Fontana1,
Francesco De Simone3, Nunziatina De Tommasi3,
Nicola Mascolo4, Luisa Pinto4
1 Dipartimento di Chimica e Tecnologie
Farmaceutiche e Alimentari, Università di Genova, Genova, Italy
2 Istituto Botanico Hanbury,
Università di Genova, Genova, Italy
3 Dipartimento di Scienze
Farmaceutiche, Università di Salerno, Salerno, Italy
4 Dipartimento di Farmacologia
Sperimentale, Univesità di Napoli, Napoli, Italy
Abstract
From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new
secoisopimarane diterpenoid with a non-specific spasmolytic activity on
histamine-, acetylcholine-, and barium chloride-induced contractions in the
isolated guinea-pig ileum was obtained. The IC50
value obtained was comparable with that obtained for papaverine. The structure
of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was
established by 1D and 2D NMR spectroscopic techniques.
Key
words
Salvia cinnabarina -
Lamiaceae - secoisopimarane-diterpene - antispasmodic acitivity
